Bloomage Biotech Evolving from a Raw Material Supplier into a Solution Provider

发布日期:2023-04-07 12:19

Being a leading hyaluronic acid enterprise in the world, Hymagic-4D (referred to as 4D hyaluronic acid), a high-profile raw material developed by Bloomage Biotech, has become a B-end "big hit" favored by the market. It has been four years since Hymagic™-4D was launched in the market, and the heat of this raw material has been increasing instead of falling. On this basis, the market has continuously derived end products such as 5D,6D,and 7D. The success of Hymagic™-4D reflects the evolution trend of Bloomage Biotech from a raw material supplier to a solution provider.

1. Comprehensive analysis of 4D hyaluronic acid

Based on the potential needs of customers, Wen Liangliang, the product manager of Bloomage Biotech Hymagic™-4D raw materials, and colleagues from Kan Hongling studio integrated hyaluronic acid with different molecular weights and different types, supplemented by a large number of efficacy tests, and finally screened out the optimal compound ratio and formulation from dozens of compositions, and then developed 4D hyaluronic acid.
The efficacy of 4D hyaluronic acid is derived from the combination of four types of hyaluronic acid.

The "skin care guardian" arranged on the outermost layer of skin is Hyacross™, with a molecular weight of more than 3 million Da. By using patented medical crosslinking technology, a three-dimensional network structure of macromolecular hyaluronic acid is formed on the skin surface like a molecular sponge, which can moisturize for 24 hours and resist external pollution such as UV and PM2.5.

The cross-linking technology and schematic diagram of Hyacross™ structure

Under Hyacross™, there are two medium molecules, Hybloom™ and Hymagic™-AcHA. Hybloom™ has a molecular weight  ranging from 200,000-1,800,000 Da, which can lock moisture on the skin surface and soften cuticular layer. The introduction of acetyl group in Hymagic™-AcHA Sodium Acetylated Hyaluronic brings lipophilicity to HA, which improves its moisture retention and repair.


miniHA, an ultra-small molecular hyaluronic acid produced by Bloomage Biotech’s patented enzyme degradation technology, acts on the dermis and can be absorbed through the skin. According to experiments, 36.2% of the hyaluronic acid was absorbed by the skin after using the miniHA solution for one hour, and 69.5% was absorbed after 24 hours. The miniHA absorbed into the skin can deeply moisturize the skin and also help in scavenging free radicals, and repairing damaged cells.


Overall, the launch of 4D hyaluronic acid has been widely welcomed by B-end skin care companies. Currently, more than 500 companies have applied 4D hyaluronic acid to products such as lotions, creams, toners, and masks. The hyaluronic acid of 5D, 6D, and 7D that appeared later is actually based on the principle and foundation of 4D, adding hyaluronic acid raw materials with higher molecular weights while remaining true to its original concept.

2. Innovation is not only about invention and creation, but also creating value for customers.

The breakthrough in microbial fermentation technology for producing hyaluronic acid is an innovation, as is the world's first enzyme degradation technology to produce hyaluronic acid with different molecular weights. Moreover, creating raw materials through collaborative technology that address unmet customer needs is also an innovation.
Bloomage Biotech believes that the vitality of an enterprise comes from continuous innovation ability and continuous profitability. In To B business, it is one-sided to only understand "innovation" as a new technology.Innovation should focus on many aspects, such as talents, technology, management, marketing, and strategy, and create greater value for the market, industry, and customers.The success of Hymagic™-4D strongly proved this point.